Understanding Extracorporeal Blood Oxygenation and Ozonation
EBOO therapy—short for Extracorporeal Blood Oxygenation and Ozonation—is an advanced form of ozone therapy that combines medical ozone with blood filtration and oxygenation. It is considered one of the most efficient and comprehensive oxidative therapies available today, primarily used to detoxify the blood, boost immune function, and improve circulation.
How Does EBOO Therapy Work?
During an EBOO session, a patient’s blood is withdrawn, filtered, infused with medical ozone and oxygen, and then returned to the body. This closed-loop system resembles dialysis but is not intended to replace kidney function.
The process includes:
- Venous Access: A needle is inserted into a vein to draw blood.
- Filtration: Blood passes through a filter that removes inflammatory molecules, damaged cells, and metabolic waste.
- Ozonation: The filtered blood is exposed to precise concentrations of medical-grade ozone, known for its antimicrobial and immunomodulating effects.
- Oxygenation: Simultaneously, the blood is enriched with pure oxygen, which helps improve tissue oxygenation.
- Reinfusion: The treated blood is safely returned to the patient’s body through a second vein.
Each session typically lasts 45–90 minutes, depending on the system used and patient tolerance.
What Are the Benefits of EBOO Therapy?
EBOO is promoted for a variety of supportive and wellness-related benefits, including:
- Systemic detoxification
- Reduction of chronic inflammation
- Immune modulation
- Improved circulation and oxygen delivery
- Enhanced energy and mental clarity
- Support for autoimmune and infectious conditions
- Adjunctive support in Lyme disease, mold toxicity, chronic fatigue, and more
While many users and clinicians report significant results, clinical research is ongoing, and EBOO should not be considered a replacement for conventional treatment.
Is EBOO Therapy Safe?
When performed by trained professionals in a medical setting using proper protocols and sterile equipment, EBOO is generally considered safe and well-tolerated.
However, it may not be suitable for everyone—particularly individuals with:
- Severe anemia
- Bleeding disorders
- Very low blood pressure
- Uncontrolled thyroid conditions
- Ozone sensitivity or allergy
A full pre-treatment evaluation is recommended before starting EBOO.
How Does It Compare to Other Ozone Therapies?
Unlike Major Autohemotherapy (MAH) or 10-pass ozone, which treat smaller blood volumes, EBOO can treat a continuous flow of blood in real time, making it more efficient and potentially more effective for systemic concerns.
| Therapy Type | Treated Blood Volume | Filtration Included? | Real-Time Treatment? |
| MAH | ~200 mL | No | No |
| 10-Pass Ozone | ~2000 mL (total) | No | No |
| EBOO | 1.5 – 2.5 Liters | Yes | Yes |
Is EBOO Therapy FDA-Approved?
As of now, EBOO therapy is not FDA-approved and is considered holistic and investigational therapy in the United States. It is, however, offered at specialized clinics under physician supervision, particularly in integrative and functional medicine settings.
While components of the procedure—such as medical oxygen, sterile saline, and IV administration—are approved for medical use, the combination of ozone with blood filtration and reinfusion has not yet received formal FDA clearance. Patients should understand that EBOO is considered an experimental adjunctive therapy and should not be used as a substitute for evidence-based medical treatment.
