EBOO (Extracorporeal Blood Oxygenation and Ozonation) is an advanced regenerative therapy that filters and oxygenates blood outside the body.

For a deep dive into the science, benefits, and how it compares to dialysis, read our complete guide: What is EBOO Therapy?

EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. This medical term describes the specific mechanism: circulating blood outside the body (“extracorporeal”) to saturate it with oxygen and ozone gas.

It is common to see variations. EBO2 is often used as a brand name for a specific protocol that combines EBOO with light therapy. EBU is typically a misspelling or shorthand. EBOO is the standard medical acronym for the extracorporeal process itself.

The EBOO protocol was developed in the late 1990s by Dr. Velio Bocci and his team at the University of Siena, Italy. While ozone therapy has existed for over a century, EBOO specifically has been used in international research for nearly 30 years and is now becoming available in private clinical settings in the US.

EBOO was pioneered by Dr. Velio Bocci, a Professor of Physiology in Italy, alongside researchers like Dr. N. Di Paolo. Their goal was to create a safer, more efficient delivery system for ozone than traditional IV methods.

The specific filtration devices used in EBOO are often FDA-registered for blood processing. However, EBOO therapy itself (the specific use of ozone for treating disease) is considered an alternative or supportive therapy and is not FDA-approved to cure specific conditions.

Safety is critical. EBOO uses sterile, single-use kits for every patient. The tubing and filters are opened fresh for your session and discarded immediately after. Your blood never touches internal machine parts, preventing any risk of cross-contamination.

Standard ozone IVs (MAH) treat only a small amount of blood (approx. 200ml) and mix it manually. EBOO processes a much larger volume (often 2–5 liters) using a continuous flow system, allowing for significantly higher oxygen saturation and simultaneous filtration of debris.

It works through a dual-action mechanism. First, the filtration system physically traps heavy metals, fats, and inflammatory proteins. Second, the infusion of ozone neutralizes pathogens (bacteria, viruses, fungi) and oxidizes toxins, turning them into inert substances the body can eliminate.

EBOO typically processes between 2 to 5 liters of blood per session, depending on the patient’s vein quality and the duration of the treatment. For many people, this represents nearly their entire blood volume.

It is similar to dialysis but with a different goal. While dialysis removes metabolic waste for kidney patients, EBOO uses a filter to trap inflammatory proteins and fats while simultaneously treating the blood with oxidative stress (ozone) to stimulate the immune system.

No. EBOO is a “closed-loop” procedure. Blood is drawn from one arm, passed through the machine, and immediately returned to your other arm. No blood is stored or discarded.

The filter captures a sludge-like residue often composed of cholesterol, lipids, dead pathogens, fungal metabolites, and heavy metals. Many patients report feeling “lighter” after these burdens are removed.

A standard treatment typically lasts between 45 to 90 minutes. This duration ensures the medical team can process a sufficient volume of blood comfortably without rushing the detoxification process.

Hydration is key. Drink plenty of water in the 24 hours leading up to your appointment to ensure your veins are easy to access. Eat a light, healthy meal beforehand to maintain your blood sugar levels.

Most patients feel minimal discomfort, limited to the initial pinch of the IV insertion. During the treatment, you simply relax. Some patients may feel a temporary wave of fatigue as the detox process begins.

This depends on your health goals. For general wellness, 1–3 sessions may suffice. For chronic conditions like Lyme or mold toxicity, a protocol of weekly sessions over 4–6 weeks is often recommended by practitioners.

Clinical observations suggest benefits include reduced systemic inflammation, improved energy and mental clarity, enhanced immune response, and faster recovery from physical exertion or illness.

Yes. Many regenerative specialists use EBOO to “clean the terrain” before stem cell therapy. By lowering inflammation and oxygenating tissues, EBOO creates an optimal environment for stem cells to survive and function.

Yes. Ozone therapy improves the “rheology” (flow properties) of blood. It makes red blood cells more flexible, allowing them to travel deeper into capillaries to deliver oxygen to tissues.

By improving micro-circulation and reducing vascular inflammation, EBOO may support better sexual function. While not a direct cure, it enhances the vascular health required for performance.

EBOO is excellent at removing free-floating fats and lipids from the bloodstream (visible in the filter), which improves vascular health. However, there is no definitive evidence that it scrubs hardened, calcified plaque from artery walls.

Many practitioners use EBOO for post-viral syndromes. The theory is that ozone’s oxidizing nature may help neutralize viral proteins and reduce the persistent inflammation associated with them, though clinical trials are still ongoing.

The filtration system can trap certain impurities, and ozone supports the body’s natural detox pathways (liver/kidneys). However, for severe heavy metal toxicity, doctors often combine EBOO with specific chelation therapies.

Ozone is a potent anti-parasitic agent. Circulating ozonated blood creates an environment where parasites struggle to survive, and the filter may capture larger pathogens, making it a useful part of a parasite cleanse.

Chronic dental infections dump bacteria into the bloodstream. EBOO helps sterilize the blood and reduce this systemic bacterial load, supporting your body while your dentist treats the local infection.

Beyond the physical detox, positive effects often include deeper sleep, brighter skin complexion, improved mood due to brain oxygenation, and increased resistance to seasonal illnesses.

EBOO uses medical-grade ozone, which is a precise mixture of pure oxygen (O2) and ozone gas (O3) generated by a certified medical device. It is distinct from atmospheric ozone (smog) and is used therapeutically to stimulate healing.

EBOO is utilized by two main groups: biohackers seeking peak performance and longevity, and individuals struggling with chronic issues such as autoimmune diseases, Lyme, mold toxicity, and chronic fatigue.

Lyme bacteria (Borrelia) are anaerobic, meaning they cannot survive in high-oxygen environments. EBOO oxygenates the blood to inhibit bacteria while simultaneously boosting the immune system’s ability to fight the infection.

Some oncologists use ozone therapy as supportive care. It may help protect healthy cells from chemotherapy toxicity and reduce side effects like fatigue. Always coordinate this with your oncology team.

EBOO is not a treatment for Lymphoma. However, it may be used to support the patient’s immune system and general well-being during conventional treatment.

EBOO is not a cure for cancer. However, integrative cancer centers often use it as a supportive therapy to improve quality of life, boost immune function, and create an oxygenated environment that is generally unfavorable to cancer cell growth.

There is no evidence that EBOO cures skin cancer. It is used strictly for systemic support and immune modulation, not as a replacement for dermatological treatment.

EBOO may support overall health and reduce inflammation in patients with prostate cancer, but it is not a direct treatment for the tumor itself.

As a supportive therapy, EBOO may help manage fatigue and inflammation in breast cancer patients. It should never replace surgery, radiation, or chemotherapy.

EBOO provides systemic immune support which can be beneficial for patients fighting cervical cancer, but it is not a specific treatment for the disease.

Yes. Arthritis is an inflammatory condition. By filtering inflammatory cytokines out of the blood and modulating the immune response, EBOO can help reduce systemic pain and improve joint mobility.

By reducing systemic inflammation and increasing oxygen delivery to the tissues, EBOO may help manage the severity of allergic and asthmatic responses.

Yes. Many patients with general joint pain or fibromyalgia report relief after EBOO, likely due to the reduction of circulating inflammatory proteins in the blood.

Absolutely. Oxygen is the fuel for healing. High levels of systemic oxygenation promote collagen production and tissue regeneration, accelerating the healing of stubborn wounds.

Conditions like eczema and psoriasis are often linked to gut health and systemic inflammation. By detoxifying the blood, EBOO can often lead to clearer, healthier skin.

EBOO is not a treatment for rectal cancer. It is an adjunctive therapy used to support the body’s natural defenses and energy levels during treatment.

Yes, this is one of its most popular uses. Mold mycotoxins suppress the immune system. EBOO helps oxidize these toxins and stimulates the immune system to identify and clear the infection.

Many clinics report success using EBOO for long-haulers. It targets the three main pillars of the condition: persistent inflammation, micro-clotting (by improving blood flow), and viral persistence.

When performed by trained medical professionals using proper protocols, EBOO has an excellent safety profile. It is a controlled, monitored procedure. Always ensure your provider is certified.

Serious risks are rare. The most common “risk” is a Herxheimer reaction—a temporary detoxification symptom where you feel flu-like fatigue as your body clears out killed pathogens. This typically passes within 24 hours.

Side effects are generally mild and may include temporary fatigue, headache, or mild bruising at the IV site.

Dangers arise if the procedure is done incorrectly. This includes potential infection (if non-sterile) or improper anticoagulation. This is why choosing a verified clinic is essential.

There are no “hidden” dangers when standard medical protocols are followed. The procedure uses established dialysis-like technology which has been used safely in medicine for decades.

No. Heparin (a blood thinner) is used during the procedure to prevent clotting in the machine. EBOO generally improves blood fluidity and circulation.

Finding a safe provider is critical. Visit EbooMedical.com to browse our directory of verified EBOO practitioners. We vet clinics for certification and equipment standards.

Currently, most standard insurance plans classify EBOO as an alternative therapy and do not cover it. However, many patients successfully use their HSA or FSA accounts to pay for treatments.

You can search by state or city on our directory at EbooMedical.com to find a practitioner in your area.

Our comprehensive directory lists verified clinics across the US and internationally. Visit EbooMedical.com to start your search.

EBOO requires advanced medical equipment, so costs are generally premium. However, prices vary by location and package deals. Check EbooMedical.com to compare clinic pricing.

There is a misconception that EBOO pulls out large, solid clots. The “debris” seen in the filter is usually a sludge of fats, fibrin, and inflammatory proteins, not solid clots. The goal is to filter the blood, not perform surgery.

We believe it represents the future of integrative healing. By combining advanced technology with the body’s natural need for oxygen, EBOO bridges the gap between biohacking and medical treatment.

We are currently compiling a comprehensive guide to EBOO therapy. Stay tuned to EbooMedical.com for the release of our official e-book and patient guides.